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Variation of cholinergic biomarkers in brain regions and blood components of captive mink |
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| Authors: | Niladri Basu Anton Scheuhammer Kirsti Rouvinen-Watt Nicole Grochowina Douglas Evans Hing Man Chan |
| Affiliation: | 1. Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA 2. National Wildlife Research Center, Canadian Wildlife Service, Environment Canada, Ottawa, Ontario, Canada, K1A 0H3 3. Department of Plant and Animal Sciences and Canadian Centre for Fur Animal Research (CCFAR), Nova Scotia Agricultural College, Truro, Nova Scotia, Canada, B2N 5E3 4. Environmental and Resource Studies, Trent University, Peterborough, Ontario, Canada, K9J 7B8 5. Community Health Program, University of Northern British Columbia, Prince George, BC, Canada, V2N 4Z9 |
| Abstract: | Studies are increasingly using cholinergic parameters as biomarkers of early neurotoxicity, but few have characterized this system in ecologically relevant model organisms. In the present study, key neurochemicals in the cholinergic pathway were measured and analyzed from discrete parts of brain and blood from captive mink (Mustela vison). Similar to other mammals, the regional distribution of cholinergic parameters in the brain could be ranked from highest to lowest as: basal ganglia > occipital cortex > brain stem > cerebellum (F 3,192?=?172.1, p? |
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