| 氯化甲基汞对大鼠脑c-fos和c-jun基因表达的影响 |
| |
| 引用本文： | 程金平,王文华,贾金平.氯化甲基汞对大鼠脑c-fos和c-jun基因表达的影响[J].环境科学,2003,24(1):52-56. |
| |
| 作者姓名： | 程金平 王文华 贾金平 |
| |
| 作者单位： | 1. 上海交通大学环境科学与工程学院,上海,200240;吉林大学环境与资源学院,长春,130026,E-mail:jp73cheng@sma.com
2. 上海交通大学环境科学与工程学院,上海,200240 |
| |
| 基金项目： | 国家自然科学基金资助项目(20177013);上海交通大学985重点科研项目(113516001) |
| |
| 摘 要： | 为了研究即刻早期基因c-fos、c-jun在氯化甲基汞(MMC)神经毒性机制中的作用,本研究应用免疫组织化学方法对皮下注射甲基汞5.0mg/kg及0.1mg/kg的大鼠脑区FOS、JUN表达水平进行观察,对照组注射生理盐水.结果表明,急性暴露3h后,暴露组大鼠脑FOS、JUN蛋白表达均高于对照组,从而表明即刻早期基因(IEG)参与了氯化甲基汞对中枢神经系统损害的毒性过程.
|
| 关 键 词： | 氯化甲基汞 c-fos c-jun 基因表达 |
| 文章编号： | 0250-3301(2003)01-05-0052 |
| 收稿时间： | 2002/1/11 0:00:00 |
| 修稿时间： | 2002年1月11日 |
Effect of Chlorimethylmercury on the Expression of c-fos and c-jun Genes in Rat Brain |
| |
| Cheng Jinping,Wang Wenhua and Jia Jinping.Effect of Chlorimethylmercury on the Expression of c-fos and c-jun Genes in Rat Brain[J].Chinese Journal of Environmental Science,2003,24(1):52-56. |
| |
| Authors: | Cheng Jinping Wang Wenhua and Jia Jinping |
| |
| Institution: | School of Environmental Science and Engineering, Shanghai Jiaotong University, Shanghai 200240, China. |
| |
| Abstract: | To study the role of immediate early genes (IEG) c-fos and c-jun in the neurotoxic mechanism of methylmercury chloride(MMC), expression of FOS and JUN in rat brains was observed by using immuohistochemical methods. In the test group MMC (5.0mg/kg and 0.1mg/kg ) was injected into rats while in the control group normal saline was injected. The results showed that after rats exposed for 3 hours, the expression of FOS and JUN in brains was higher than those of the control rats, the results indicated that IEG could participate in the neurological toxicity induced by chlorimethylmercury. |
| |
| Keywords: | methylmercury chloride c-fos c-jun gene expression |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
| 点击此处可从《环境科学》浏览原始摘要信息 |
| 点击此处可从《环境科学》下载免费的PDF全文 |
