| Studies on metabolism of 2-naphthylamine and its activation mechanism |
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| 引用本文： | Li Tingshu,Dai Tianyou,Pei Shu,Dai Qianhuan. Studies on metabolism of 2-naphthylamine and its activation mechanism[J]. 环境科学学报(英文版), 1991, 3(1): 101-108 |
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| 作者姓名： | Li Tingshu Dai Tianyou Pei Shu Dai Qianhuan |
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| 作者单位： | Li Tingshu，Dai Tianyou，Pei Shu and Dai QianhuanDepartment of Chemical and Environmental Engineering，Beijing Polytechnic University，Beijing，ChinaChinese Environmental Monitor Centre，Beijing，ChinaBeijing Institute of Labour Hygiene and Occupational Diseases，Beijing，China |
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| 基金项目： | This work is financed by Chinese Academy of Sciences. |
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| 摘 要： | 2-naphthylamine was incubated with induced rat liver microsome S9 preparation and the metabolites were separated through HPLC. The following products were identified: 2-amino-5-naphthol, 2-amino-6-naphthol, 2-amino-7-naphthol and 2-amino-8-naphthol. The yields of these four metabolites are varying in quantity, and the relative contents of 2-amino-8-, -5-, -6- and -7-naphthol are 52.6%, 28.5%, 14.0% and 4.9% respectively. These results are consistent with the quantitative HMO calculation and inference based upon Di-region theory, i.e., the metabolisms of aryl amines on extra-ring (assigned the ring without the substituent of amino group) are through the epoxidation and then NIH shift, but are not the direct hydroxylation in the formation of phenols. It is shown that both the amino group and the carbon atoms on the extra-ring play duality roles of activation and detoxification in metabolism.
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| 关 键 词： | 2-naphthylamine 2-aminonaphthols metabolism Di-region theory. |
| 收稿时间： | 1989-10-30 |
Studies on metabolism of 2-naphthylamine and its activation mechanism |
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| Li Tingshu,Dai Tianyou,Pei Shu and Dai Qianhuan. Studies on metabolism of 2-naphthylamine and its activation mechanism[J]. Journal of environmental sciences (China), 1991, 3(1): 101-108 |
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| Authors: | Li Tingshu Dai Tianyou Pei Shu Dai Qianhuan |
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| Affiliation: | Li Tingshu,Dai Tianyou,Pei Shu and Dai QianhuanDepartment of Chemical and Environmental Engineering,Beijing Polytechnic University,Beijing,ChinaChinese Environmental Monitor Centre,Beijing,ChinaBeijing Institute of Labour Hygiene and Occupational Diseases,Beijing,China |
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| Abstract: | 2-naphthylamine was incubated with induced rat liver microsome S9 preparation and the metabolites were separated through HPLC. The following products were identified: 2-amino-5-naphthol, 2-amino-6-naphthol, 2-amino-7-naphthol and 2-amino-8-naphthol. The yields of these four metabolites are varying in quantity, and the relative contents of 2-amino-8-, -5-, -6- and -7-naphthol are 52.6%, 28.5%, 14.0% and 4.9% respectively. These results are consistent with the quantitative HMO calculation and inference based upon Di-region theory, i.e., the metabolisms of aryl amines on extra-ring (assigned the ring without the substituent of amino group) are through the epoxidation and then NIH shift, but are not the direct hydroxylation in the formation of phenols. It is shown that both the amino group and the carbon atoms on the extra-ring play duality roles of activation and detoxification in metabolism. |
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| Keywords: | 2-naphthylamine 2-aminonaphthols metabolism Di-region theory. |
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