Recurrent congenital toxoplasmosis in a woman with lupus erythematosus |
| |
| Authors: | Claude D'Ercole Léon Boubli Jacqueline Franck Michel Casta Jean-Robert Harle Catherine Chagnon Ludovic Cravello Michèle Leclaire Bernard Blanc |
| |
| Institution: | 1. Service de Gynécologie-Obstétrique B, Hǒpital de la Conception, 13385 Marseille Cedex 5, France;2. Laboratoire de Parasitologie, Faculté de la Timone, Marseille, France;3. Service de Médecine Interne, Hǒpital de la Timone, Marseille, France;4. Service de Néonatologie, Hǒpital de la Conception, Marseille, France |
| |
| Abstract: | We describe the case of a patient with systemic lupus erythematosus, treated by corticosteroids, who presented during two successive pregnancies with serological reactivation of toxoplasmosis associated with fetal lesions. The first infected fetus died in utero with signs of hydrops. The second fetus was treated in utero with a combination of sulfadoxine and pyrimethamine, administered to the mother, and is now well. The increasing number of immunocompromised pregnant patients with immunity to Toxoplasma gondii may lead to a higher risk of reactivation of maternal toxoplasmosis and congenital infection. |
| |
| Keywords: | congenital toxoplasmosis immunodeficiency prenatal diagnosis fetal therapy |
|
|
