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Micronucleus induction by oxidative metabolites of trichloroethylene in cultured human peripheral blood lymphocytes: a comparative genotoxicity study |
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| Authors: | Meenu Varshney Abhijit Chandra L. K. S. Chauhan Sudhir K. Goel |
| Affiliation: | 1. Petroleum Toxicology Division, Indian Institute of Toxicology Research (IITR), Council of Scientific and Industrial Research, P.O. Box No. 80, Mahatma Gandhi Marg, Lucknow, 226001, India 2. Surgical Gastroenterology Division, Chhatrapati Shahuji Maharaj Medical University, Chowk, Lucknow, 226003, India 3. Biochemistry Division, All India Institute of Medical Science, Saket Nagar, Bhopal, 462024, India |
| Abstract: | The genotoxic effects of oxidative metabolites of trichloroethylene (TCE), namely chloral hydrate, trichloroacetic acid (TCA), dichloroacetic acid (DCA), and trichloroethanol (TCEOH) were examined in human peripheral blood lymphocytes. In this context, lymphocytes were exposed in vitro to 25, 50, and 100 μg/ml concentrations of these metabolites separately for a period of 48 h and examined for micronucleus (MN) induction through flow cytometer. At 50 μg/ml TCE metabolites, TCA (6.33?±?0.56 %), DCA (5.06?±?0.55), and TCEOH (4.70?±?1.73) induced highly significant (p?p? |
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