| 联苯胺对大鼠肝脏线粒体同工酶的影响 |
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| 引用本文： | 梅启明,周培疆.联苯胺对大鼠肝脏线粒体同工酶的影响[J].中国环境科学,2009,29(9):997-999. |
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| 作者姓名： | 梅启明 周培疆 |
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| 作者单位： | 1. 武汉大学生命科学学院,湖北,武汉,430072;武汉大学园林与环卫中心,湖北,武汉,430072
2. 武汉大学环境科学系,湖北,武汉,430072 |
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| 摘 要： | 采用不同浓度的联苯胺(50,100,200mg/kg)对大鼠进行体内染毒,利用聚丙烯酰胺凝胶电泳法分析了大鼠肝脏线粒体SOD、GSH-Px、COX和Ca2+-ATPase同工酶的表达差异.结果表明,同工酶COX-L和ATPase-L只在50mg/kg低剂量浓度联苯胺处理组中特异表达.分析认为,低浓度联苯胺经体内代谢活化后,对大鼠肝脏线粒体COX-L和ATPase-L的表达具有诱导作用;当联苯胺浓度达到200mg/kg时,对SOD、GSH-Px、COX和Ca2+-ATPase同工酶的表达均产生明显的抑制作用.
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| 关 键 词： | 联苯胺 体内染毒 大鼠肝脏 线粒体 同工酶 |
| 收稿时间： | 2009-01-08; |
Effect of benzidine on mitochondria isozymes of liver of mice |
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| MEI Qi-ming,ZHOU Pei-jiang.Effect of benzidine on mitochondria isozymes of liver of mice[J].China Environmental Science,2009,29(9):997-999. |
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| Authors: | MEI Qi-ming ZHOU Pei-jiang |
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| Abstract: | By injecting different concentrations of benzidine (0, 50, 100, and 200mg/kg) into rats, the effect of benzidine on the expression of SOD, GSH-Px, COX and Ca2+-ATPase in liver mitochondrion were investigated by using polyacrylamid gel electrophoresis. COX-L and Ca2+-ATPase-L were expressed at 50mg/kg of benzidine. The liver mitochondrion was induced to express COX-L and Ca2+-ATPase-L by metabolizing benzidine at low concentration while the expression of the four isozymes was suppressed at higher concentration of benzidine (3200mg/kg). |
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| Keywords: | benzidine internal toxication liver of mice mitochondria isozymes |
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