Erratum |
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Authors: | Diethard Baron |
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Institution: | 1. Boehringer Mannheim GmbH Fakult?t für Biologie der Universit?t, W-7400, Tübingen, Bundesrepublik Deutschland
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Abstract: | Murine monoclonal antibodies (mabs) are produced in either mouse ascites or bioreactors (spinner culture, stirred-tank reactor, airlift reactor, hollow-fiber reactor). Human mabs are produced solely in bioreactors. Encapsulation represents a special technology. Hybridoma cells have to be adapted prior to growth in bioreactors. Of crucial importance is the construction of over-producing cell lines by cell- and gene-technological methods. Manipulated cell lines often produce modified mabs. |
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