| DNA链断裂作为醛类污染物接触标志物的研究 |
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| 引用本文： | 袭著革,高进林.DNA链断裂作为醛类污染物接触标志物的研究[J].云南环境科学,2000,19(Z1):50-52. |
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| 作者姓名： | 袭著革 高进林 |
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| 作者单位： | 军事医学科学院卫生学环境境医学研究所!天津300050(袭著革)，云南陆军预备役步兵师卫生科!云南昆明650000(高进林) |
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| 摘 要： | 应用单细胞凝胶电泳技术 ,通过对小鼠脾淋巴细胞染毒试验 ,测定了甲醛、乙醛、丙稀醛单独及联合作用下对细胞DNA分子链断裂损伤。结果表明 ,3种醛均能引起DNA分子发生链断裂 ,对于乙醛和丙稀醛存在明确的剂量 -反应关系 ,3种化合物还还存在着一定的协同作用。上述结果提示醛类污染物潜在致癌性的一个可能机制以及DNA断裂作为醛类化合物接触标志物的可能性。
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| 关 键 词： | 醛类污染物 DNA链断裂 接触标志物 |
| 修稿时间： | 2000-04-20 |
DNA Strand Breakage as Possible Marker of Exposure to Aldehyde Pollutants |
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| Xi Zhuge,Gao Jinlin.DNA Strand Breakage as Possible Marker of Exposure to Aldehyde Pollutants[J].Yunnan Environmental Science,2000,19(Z1):50-52. |
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| Authors: | Xi Zhuge Gao Jinlin |
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| Institution: | Xi Zhuge 1 Gao Jinlin 2 |
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| Abstract: | Through the lymphocytes of mouse spleen exposed single or jointed aldehydes,we examine the amount of DNA Strand Breakage (DSB) formation by comet assay.The results show that three kinds of aldehydes could induce DSB and there exists significant dose-response relationship for acetaldehyde and acrolein.The aldehydes also have synergetic functions.Our data indicates a possible mechanism of aldehyde pollutants potential carcinogenicity and DSB can be used as the biomarker of exposure to aldehyde pollutants. |
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| Keywords: | aldehyde pollutants DNA Strand Breakage biomarkers of exposure |
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