Distribution of persistent organic pollutants in serum,omental, and parietal adipose tissue of French women with deep infiltrating endometriosis and circulating versus stored ratio as new marker of exposure |
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| Institution: | 1. LUNAM Université, Oniris, USC 1329 Laboratoire d''Etude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes, France;2. Service de gynécologie-obstétrique, CIC FEA, Hôpital Mère Enfant, CHU Hôtel Dieu, Nantes, France;3. INRA, Nantes F-44307, France;4. Plateforme Biometrie, CHU Hôtel Dieu, Nantes, France;1. Department of Physical and Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, Ontario M1C 1A4, Canada;2. Environmental Health Science and Research Bureau, Health Canada, 4908D – 269 Laurier Avenue West, Ottawa, Ontario K1A 0K9, Canada;3. ARC Arnot Research & Consulting, 36 Sproat Avenue, Toronto, Ontario M4M 1W4, Canada;4. Department of Biology, University of Ottawa, 30 Marie-Curie Private, Ottawa, Ontario K1N 6N5, Canada;1. Toxicology Unit, Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Plaza Dr. Pasteur s/n, 35016, Las Palmas de Gran Canaria, Spain;2. Instituto Canario de Investigación del Cáncer (ICIC), Plaza Dr. Pasteur s/n, 35016, Las Palmas de Gran Canaria, Spain;3. Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBERObn), Plaza Dr. Pasteur s/n, 35016, Las Palmas de Gran Canaria, Spain;4. Infectious Diseases and Tropical Medicine Unit, Hospital Universitario Insular de Gran Canaria, Avda. Marítima del Sur, 35016 Las Palmas de Gran Canaria, Spain;5. Department of Medical and Surgery Sciences, Universidad de Las Palmas de Gran Canaria, Plaza Dr. Pasteur s/n, 35016 Las Palmas de Gran Canaria, Spain |
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| Abstract: | Several studies have assessed the potential role of environmental chemicals in the onset, growth, and/or physiopathology of endometriosis. However, their contour in terms of considered exposure markers remains limited. The present study aimed to characterize the internal exposure levels of 78 persistent organic pollutants (POPs, including dioxins, polychlorobiphenyls, brominated flame retardants and organochlorine pesticides) in a set of 113 adult French women (45 controls, 68 cases), and to characterize the distribution of these POPs within three biological compartments (omental adipose tissue, parietal adipose tissue, and serum). For all targeted substances, the correlation between the concentrations measured in omental versus parietal adipose tissue was found strongly significant (p < 0.0001). An equivalence of the measures performed in parietal and omental adipose tissue was moreover observed with median levels of 6.4 vs. 7.4 pg/g l.w. for WHO-TEQ2005 PCDD/F, 4.5 vs. 4.7 pg/g l.w. for WHO-TEQ2005 dl-PCB, 137.1 vs. 147.9 ng/g l.w. for sum of 6 ndl-PCB, and 2.1 vs. 2.0 ng/g l.w. for sum of 7 i-PBDE, respectively. The same observation was made for individual targeted OCs compounds. Significant correlations were also observed between these concentrations determined in adipose tissue and those measured in serum for dioxins (WHO-TEQ2005 PCDD/F = 6.1 pg/g l.w), PCBs (WHO-TEQ2005 dl-PCB = 3.6 pg/g l.w., sum of 6 ndl-PCB = 81.1 ng/g l.w.), and brominated flame-retardants (sum of 7 i-PBDE = 0.9 ng/g l.w.). The circulating versus stored ratio of some exposure markers (Sum PCDDs, 1,2,3,6,7,8-HxCDF, slightly versus highly chlorinated PCBs ratio, PBDE 99 and PBB 153) was found statistically different for control and case individuals. These extended exposure data from deep infiltrating endometriosis patients are the first ones available for France and give a new insight about the equilibrium of chemicals between storage and circulating compartments that should be further considered as new marker of exposure in the context of exposure-health relationship studies. |
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