Associations of gestational and early life exposures to ambient air pollution with childhood respiratory diseases in Shanghai,China: A retrospective cohort study |
| |
| Institution: | 1. Department of Building Environment and Energy Engineering, School of Environment and Architecture, University of Shanghai for Science and Technology (USST), Shanghai, China;2. Tongji Architectural Design (Group) Company Limited (TJAD), Shanghai, China;3. Shanghai Environmental Monitoring Center (SEMC), Shanghai, China;4. R&B Technology (Shanghai) Company Limited, Shanghai, China;5. Department of Thermal Energy and Power Engineering, Shandong Jiaotong University, Jinan, China;6. School of Environmental Science and Engineering, Tianjin University, Tianjin, China;7. Department of Building Science, Tsinghua University, Beijing, China;1. Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan;2. Department of Environmental and Occupational Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan;3. Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan;4. Department of Pediatrics, National Taiwan University Hospital Yun-Lin Branch, Yunlin, Taiwan;5. Department of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan;6. Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore;7. Department of Public Health, Tzu Chi University, Hualian County, Taiwan;8. Department of Pediatrics, Cathy General Hospital, Taipei, Taiwan;9. Department of Public Health, National Taiwan University College of Public Health, Taipei, Taiwan |
| |
| Abstract: | BackgroundAssociations of ambient air pollutants with respiratory health are inconsistent.ObjectivesWe analyzed the associations of gestational and early life exposures to air pollutants with doctor-diagnosed asthma, allergic rhinitis, and pneumonia in children.MethodsWe selected 3358 preschool children who did not alter residences after birth from a cross-sectional study in 2011–2012 in Shanghai, China. Parents reported children's respiratory health history, home environment, and family lifestyle behaviors. We collected daily concentrations of sulphur dioxide (SO2), nitrogen dioxide (NO2), and particulate matter with an aerodynamic diameter ≤ 10 μm (PM10) during the child's total lifetime (2006–2012) for each district where the children lived. We analyzed the associations using logistic regression models.ResultsAfter adjusting for covariates and the other studied pollutants, we found that exposure to NO2 (increment of 20 μg/m3) during the first year of life was significantly associated with asthma odds ratio (OR) = 1.77; 95% confidence interval (CI): 1.29–2.43] and allergic rhinitis (OR = 1.67; 95% CI: 1.07–2.61). Exposure to NO2 during gestation, the first two and three years, and over total lifetimewas all consistently associated with increased odds of allergic rhinitis. Quartiles of NO2 concentration during different exposure periods showed a slight dose–response relationship with the studied diseases. These diseases had significant associations with pollutant mixtures that included NO2, but had no significant association with exposures to SO2 and PM10 individually or in mixtures.ConclusionsGestational and early life exposures to ambient NO2 are risk factors for childhood respiratory diseases. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
