Prenatal diagnosis of congenital nephrosis by in utero kidney biopsy |
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| Authors: | Ronald J Wapner Thomas M Jenkins Neil Silverman Marion Kaufmann Cheryl Hannau Peter McCue |
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| Institution: | 1. Division of Maternal–Fetal Medicine, Department of Obstetrics and Gynecology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA, USA;2. Department of Pathology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA, USA |
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| Abstract: | The diagnosis of congenital nephrosis is difficult during the antepartum period. The combination of an elevated amniotic fluid alpha-fetoprotein, a negative acetylcholinesterase, and a negative ultrasound examination is highly indicative of congenital nephrosis; however, these findings can also be associated with a normal gestation. This is the first report of pathologic confirmation of congenital nephrosis from an in utero fetal kidney biopsy. Copyright © 2001 John Wiley & Sons, Ltd. |
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| Keywords: | fetal biopsy nephrosis prenatal diagnosis |
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