Histopathological findings of the nose of Down syndrome abortuses |
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Authors: | S F Wong W F Ng L C Ho |
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Institution: | 1. Department of Obstetrics and Gynaecology, Princess Margaret Hospital, Hong Kong SAR;2. Department of Pathology, Princess Margaret Hospital, Hong Kong SAR |
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Abstract: | Recent reports of absent nasal bone in fetuses with Down syndrome have sparked much interest in the use of this finding for the screening of Down syndrome. We describe the histopathological findings of nasal bones of two fetuses with Down syndrome, one with absence and the other with normal ossification of the nasal bone. We propose that histopathological examination of the nasal bone could improve the accuracy of diagnosis of nasal hypoplasia among Down syndrome abortuses. Copyright © 2003 John Wiley & Sons, Ltd. |
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Keywords: | first-trimester screening nasal bone Down syndrome |
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