Maternal serum activin A and inhibin A in trisomy 18 pregnancies at 10–14 weeks |
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| Authors: | Kevin Spencer Adolfo W Liao Charas Y T Ong Nicola J Flack Kypros H Nicolaides |
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| Institution: | 1. Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex RM3 0BE, UK;2. Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, Denmark Hill, London SE5 8RX, UK |
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| Abstract: | In 45 cases of trisomy 18 and 493 control pregnancies at 10–14 weeks of gestation, maternal serum inhibin A, total activin A, free β-hCG and PAPP-A were measured. In the trisomy 18 pregnancies the median values were 0.74 MoM for inhibin A, 1.23 MoM for activin A, 0.38 MoM for free β-hCG and 0.16 MoM for PAPP-A. The degree of deviation from normal in the levels of inhibin and activin is small in comparison with free β-hCG and PAPP-A and they are therefore unlikely to be of value in improving the sensitivity of 90% for a 1% false-positive rate achieved by screening with fetal nuchal translucency and maternal serum free β-hCG and PAPP-A. Copyright © 2001 John Wiley & Sons, Ltd. |
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| Keywords: | inhibin activin free β-hCG PAPP-A nuchal translucency trisomy 18 first trimester aneuploidy prenatal screening |
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