城市大气颗粒物毒性效应及机制的研究进展

大气颗粒物（PM）严重影响人体的健康，其与人类多种疾病的发生存在着明显的暴露-效应关系.本文简述了大气颗粒物的组分和来源，从大气颗粒物的呼吸系统毒性、心血管毒性、免疫毒性、神经毒性、遗传毒性等方面，系统地阐述了其对人体健康的危害，并对大气颗粒物的毒性机制进行了总结和讨论，指出了目前相关研究中存在的问题，展望了该领域的研究趋势，为后续研究和控制大气颗粒物的健康危害提供相应的科学参考依据.

Research progress on toxicological characteristics and mechanisms of urban atmospheric particulate matters

Atmospheric particulate matters (PM) seriously affect the human health and the strong exposure-response relationship between PM and many human diseases has been confirmed. In this paper, the components and sources of particulate matter were briefly introduced and the harms to human health were systematically summarized on the aspects of respiratory toxicity, cardiovascular toxicity, immune toxicity, neurotoxicity, and genotoxicity. Additionally, the mechanisms of toxicity of particulate matter were summarized and discussed. We also pointed out the problems in the current study and the trends of future research. It will be contributable to the control of atmospheric particle pollution and provide the appropriate scientific reference for the studies on toxicological mechanisms of PM health damage.