| 氟喹诺酮污染对淡水水生环境的影响—综述 |
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| 作者姓名： | - |
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| 摘 要： | 截至目前，环境中抗生素的行为及其对生态毒性的影响仍被忽视。这一课题的范畴是宽泛的，涉及到广泛的生物体，包括栖居在各种水生生态系统中的微生物，藻类，无脊椎动物和脊椎动物等。改变这种系统中任何一个组成的平衡破坏了整个系统的平衡。在人类和动物医学中，氟喹诺酮的制造和频繁使用引起了对微生物抗生素耐药性流行率增加的高度关注，而且，除此之外，通过各种途径进入环境生态系统的抗生素母体和代谢物化合物的归趋也引起了环境影响关注。相关研究集中在分析环境样品中氟喹诺酮的存留浓度，并且经常使用动物评估模型来测试急性毒性，但是仍然不清楚在水生环境中低水平慢性接触对生命形态的生态毒性影响中起什么作用。本综述的目的是评估氟喹诺酮在动物和人类医学中的使用水平，确定其传播的途径，突出在淡水环境中的生态毒理学影。
精选自Nicol Janecko, Lucie Pokludova, Jana Blahova, Zdenka Svobodova, Ivan Literak. Implications of fluoroquinolone contamination on the fresh water aquatic environment -A review. Environmental Toxicology and Chemistry: Volume 35, Issue 11, pages 2647–2656, November 2016.
DOI: 10.1002/etc.3552
详情请见http://onlinelibrary.wiley.com/doi/10.1002/etc.3552/full
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Implications of fluoroquinolone contamination on the fresh water aquatic environment -A review |
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| -.Implications of fluoroquinolone contamination on the fresh water aquatic environment -A review[J].Asian Journal of Ecotoxicology,2016,11(6). |
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| Authors: | Nicol Janecko Lucie Pokludov Jana Blahov Zdenka Svobodov Ivan Literak |
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| Institution: | 1. Department of Biology and Wildlife Diseases, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic
2. Institute for State Control of Veterinary Biologicals and Medicines, Brno, Czech Republic
3. Department of Veterinary Public Health and Animal Welfare, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic
4. Central European Institute of Technology, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic |
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| Abstract: | Until recently, the behaviour of antibiotics and their ecotoxicological impact have been overlooked in the environment. The topic is broad and encompasses a wide range of organisms including microorganisms, algae, invertebrates and vertebrates inhabiting various aquatic ecosystems. Changing the equilibrium of any one component in such systems disrupts the balance of the whole system. The manufacturing and frequent use of fluoroquinolones in human and animal medicine raises great concern over the increase of antibiotic resistance prevalence in microorganisms, however, in addition to that, the fate of antibiotic parent and metabolite compounds entering environmental ecosystems through various pathways raise environmental impact concerns. Research has focused on the concentrations present in environmental samples and often use animal assessment models to test acute toxicity, however it remains unclear what role low level chronic exposure plays in ecotoxicological effects on lifeforms in aquatic environments. The aim of the present review was to assess the levels of fluorquinolone use in animal and human medicine, determine the pathways of dissemination and highlight the ecotoxicological implications in fresh-water environments.
View more in http://onlinelibrary.wiley.com/doi/10.1002/etc.3552/full |
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| Keywords: | Antibiotics Ecotoxicity Residues Freshwater ecology |
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