| 离子液体[C14mim]Br对大鼠亚慢性毒性的初步研究 |
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| 引用本文： | 许峰,苑华飞,隋孟璋,张亚婷,李坡,刘庆,罗春云,徐红梅.离子液体[C14mim]Br对大鼠亚慢性毒性的初步研究[J].环境科学学报,2020,40(1):299-305. |
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| 作者姓名： | 许峰 苑华飞 隋孟璋 张亚婷 李坡 刘庆 罗春云 徐红梅 |
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| 作者单位： | 合肥工业大学,食品与生物工程学院,药物科学与工程系,合肥230009,合肥工业大学,食品与生物工程学院,药物科学与工程系,合肥230009,合肥工业大学,食品与生物工程学院,药物科学与工程系,合肥230009,合肥工业大学,食品与生物工程学院,药物科学与工程系,合肥230009,合肥工业大学,食品与生物工程学院,药物科学与工程系,合肥230009,合肥工业大学,食品与生物工程学院,药物科学与工程系,合肥230009,合肥工业大学,食品与生物工程学院,药物科学与工程系,合肥230009,合肥工业大学,食品与生物工程学院,药物科学与工程系,合肥230009 |
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| 基金项目： | 安徽省自然科学基金面上项目（No.1708085MB51）；合肥工业大学大学生创新性实验项目（No.2017CXCY487） |
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| 摘 要： | 研究了离子液体溴化-1-十四烷基-3-甲基咪唑盐(C_(14)mim]Br)对大鼠的亚慢性毒性.实验设立3个染毒组(2.5、5、10 mg·kg~(-1))和1个对照组,对大鼠经口染毒90 d后,分别考察大鼠的体重、血清生化指标、脏体指数、组织形态学的变化.结果表明,与对照组相比,染毒组大鼠的体重增长随着染毒剂量的增加而降低,肝脏/体重系数增大,其血清中碱性磷酸酶(ALP)、丙氨酸氨基转移酶(ALT)、天门冬氨酸转氨酶(AST)、直接胆红素(DBIL)和和球蛋白(GLB)水平均明显升高,A/G(ALB/GLB)、血清总蛋白(TP)值则明显下降.病理检查结果显示,染毒组大鼠的肝脏、肾脏及肺均有不同程度的损伤及病变.研究表明,C_(14)mim]Br亚慢性染毒对大鼠的肝肾均有损伤,且其毒性呈一定的剂量依赖性.
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| 关 键 词： | 离子液体 溴化-1-十四烷基-3-甲基咪唑盐 大鼠 亚慢性毒性 |
| 收稿时间： | 2019/6/13 0:00:00 |
| 修稿时间： | 2019/8/7 0:00:00 |
Preliminary study on subchronic toxicity of ionic liquid[C14mim]Br in rats |
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| XU Feng,YUAN Huafei,SUI Mengzhang,ZHANG Yating,LI Po,LIU Qing,LUO Chunyun and XU Hongmei.Preliminary study on subchronic toxicity of ionic liquid[C14mim]Br in rats[J].Acta Scientiae Circumstantiae,2020,40(1):299-305. |
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| Authors: | XU Feng YUAN Huafei SUI Mengzhang ZHANG Yating LI Po LIU Qing LUO Chunyun and XU Hongmei |
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| Institution: | Department of Pharmaceutical Science and Engineering, School of Food and Bioengineering, Hefei University of Technology, Hefei 230009,Department of Pharmaceutical Science and Engineering, School of Food and Bioengineering, Hefei University of Technology, Hefei 230009,Department of Pharmaceutical Science and Engineering, School of Food and Bioengineering, Hefei University of Technology, Hefei 230009,Department of Pharmaceutical Science and Engineering, School of Food and Bioengineering, Hefei University of Technology, Hefei 230009,Department of Pharmaceutical Science and Engineering, School of Food and Bioengineering, Hefei University of Technology, Hefei 230009,Department of Pharmaceutical Science and Engineering, School of Food and Bioengineering, Hefei University of Technology, Hefei 230009,Department of Pharmaceutical Science and Engineering, School of Food and Bioengineering, Hefei University of Technology, Hefei 230009 and Department of Pharmaceutical Science and Engineering, School of Food and Bioengineering, Hefei University of Technology, Hefei 230009 |
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| Abstract: | To investigate the sub-chronic toxicity of ionic liquid bromide 1-tetradecyl-3-methyl imidazole salt (C14mim]Br) in rats,C14mim]Br were administered to rats by intra-gastric administration at three different dosages (2.5, 5, 10 mg·kg-1) for 90 days. Also one blank control group (intra-gastric administration with only water) were established in the experiment. Then the changes of body weight, serum biochemical index, visceral body index and histomorphology in rats were investigated. Results:Compared with the blank control group, there showed a decreasing trend of body weight increase inC14mim]Br groups. And this effect showed in a dose-dependent manner. The ratio of liver to body (the coefficients of liver) was positively related with theC14mim]Br dosages. The serum levels of ALP, ALT, AST, DBIL and GLB were significantly increased, while A/G, TP values were significantly decreased. The histopathology showed that the liver and kidney tissue in rats with different dosages ofC14mim]Br administration were damaged in different degrees. Conclusion:Sub-chronic exposure toC14mim]Br could damage the liver and kidney in rats and its toxicity showed in a dose-dependent manner. |
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| Keywords: | ionic liquid bromide 1-tetradecyl-3-methyl imidazole salt rat subchronic toxicity |
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