Biological evidences than human osteoarthritic chondrocytes could be affected by electromagnetic fields with extremely low-frequency or new TAMMEF system |
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Authors: | A Albanese E Battisti N Giordano A Vittoria M Rigato R Leoncini D Vannoni |
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Institution: | (1) TAMMEF CENTRE, University of Siena, Ospedale S. Maria alle Scotte, Strada delle Scotte 1, Siena, Italy;(2) Department of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University of Siena, Ospedale S. Maria alle Scotte, Strada delle Scotte 1, Siena, Italy |
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Abstract: | Osteoarthritis (OA) is a chronic degenerative condition involving the joints caused by metabolic changes in chondrocytes metabolism.
Treatment with magnetic fields (EMFs) produces benefits to patients affected by this pathology. The present research has the
aim to investigate, by a proteomic approach, the effect of magnetic fields on cultured chondrocytes, because EMFs interferes
greatly with OA chondrocytes metabolism. Human osteoarthritic chondrocytes were obtained from the femur head of osteoarthritis
adult patients and were cultured under standard conditions and exposed for precise times both to extremely low-frequency (ELF;
100-Hz) electromagnetic fields and to the Therapeutic Application of Musically Modulated Electromagnetic Fields (TAMMEF),
which are characterized by variable frequencies, intensities, and wave shapes. We tested the effects of the different exposure
by 2-DE analysis and demonstrated that chondrocytes metabolism was highly influenced by the treatment with EMFs; in fact many
proteins change their expression after the stimulation, but differently, depending on whether we use ELF or TAMMEF system. |
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