| 利用磷霉素生产盐渣合成阻垢剂 |
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| 引用本文： | 戢峻,刘娇,罗勇,丁一刚,邹华伟,杨光宏.利用磷霉素生产盐渣合成阻垢剂[J].化工环保,2012,32(1):53-56. |
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| 作者姓名： | 戢峻 刘娇 罗勇 丁一刚 邹华伟 杨光宏 |
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| 作者单位： | 1. 武汉工程大学湖北省新型反应器与绿色化学工艺重点实验室,湖北武汉,430073
2. 中国医药集团武汉医药设计院,湖北武汉,430077 |
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| 基金项目： | 湖北省高等学校青年教师深入企业行动计划项目，武汉工程大学校长基金项目，湖北省化学实验教学示范中心创新实验基金项目 |
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| 摘 要： | 将磷霉素生产盐渣经水解得到右旋磷霉素二钠,再通过亲核取代反应得到可用作循环冷却水阻垢剂的氨基二乙基(1-甲基-2-羟基)膦酸四钠(ADMHP·Na4),并用FTIR表征了产物结构.实验结果表明:在取代反应温度为25℃、取代反应时间为2h、n(氨水)∶n(右旋磷霉素二钠)=8的条件下,由右旋磷霉素二钠制备ADMHP·Na4,收率可达83.87％.处理1t盐渣可创造利润3 080元.当ADMHP·Na4质量浓度为30 mg/L,水样温度为60℃时,ADMHP·Na4对CaCO3的阻垢效果较好,阻垢率可达91.47％.
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| 关 键 词： | 磷霉素 右旋磷霉素二钠 氨基二乙基(1-甲基-2-羟基)膦酸四钠 阻垢剂 综合利用 |
Synthesis of Scale Inhibitor for Circulating Cooling Water from Salt Slag in Fosfomycin Production |
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| Ji Jun
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Liu Jiao
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Luo Yong
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Ding Yigang
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Zou Huawei
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Yang Guanghong.Synthesis of Scale Inhibitor for Circulating Cooling Water from Salt Slag in Fosfomycin Production[J].Environmental Protection of Chemical Industry,2012,32(1):53-56. |
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| Authors: | Ji Jun Liu Jiao Luo Yong Ding Yigang Zou Huawei Yang Guanghong |
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| Institution: | 1(1.Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical Technology,Wuhan Institute of Technology,Wuhan Hubei 430073,China;2.Wuhan Pharmaceutical Industry Design Institute,SINOPHARM,Wuhan Hubei 430077,China) |
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| Abstract: | The salt slag in fosfomycin production was hydrolyzed to obtain dextrofosfomycin disodium,and then to prepare tetra sodium salt of amino diethyl(1-methyl-2-hydroxy)phosphonic acid(ADMHP·Na4)by nucleophilic substitution reaction,which can be used as scale inhibitor for circulating cooling water.The structure of the product was characterized by FTIR.The experimental results show that:Under the conditions of reaction temperature 25 ℃,reaction time 2 h,n(NH3·H2O)∶n(dextrofosfomycin disodium)= 8,the yield of ADMHP·Na4 produced from dextrofosfomycin disodium can reach 83.87%.About 3 080 yuan of profit can be created through the treatment of 1 t salt slag.When the mass concentration of ADMHP·Na4 is 30 mg/L and the water temperature is 60 ℃,ADMHP·Na4 has a better inhibition effect on CaCO3 scale and the scale inhibition efficiency can reach 91.47%. |
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| Keywords: | fosfomycin dextrofosfomycin disodium tetra sodium salt of amino diethyl(1-methyl-2-hydroxy)phosphonic acid scale inhibitor nucleophilic substitution |
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