Exposure of Chronic Obstructive Pulmonary Disease Patients to Particulate Matter: Relationships between Personal and Ambient Air Concentrations |
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| Authors: | Stefanie T. Ebelt A. John Petkau Sverre Vedal Teri V. Fisher Michael Brauer |
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| Affiliation: | 1. The University of British Columbia, School of Occupational and Environmental Hygiene , Vancouver , USA;2. The University of British Columbia, Department of Statistics , Vancouver , USA;3. The University of British Columbia, Department of Medicine , Vancouve , USA;4. The University of British Columbia, School of Occupational and Environmental Hygiene and the Department of Medicine , Vancouver , USA |
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| Abstract: | ![]()
ABSTRACT Most time-series studies of particulate air pollution and acute health outcomes assess exposure of the study population using fixed-site outdoor measurements. To address the issue of exposure misclassification, we evaluate the relationship between ambient particle concentrations and personal exposures of a population expected to be at risk of particle health effects. Sampling was conducted within the Vancouver metropolitan area during April-September 1998. Sixteen subjects (non-smoking, ages 54-86) with physician-diagnosed chronic obstructive pulmonary disease (COPD) wore personal PM2 5 monitors for seven 24-hr periods, randomly spaced approximately 1.5 weeks apart. Time-activity logs and dwelling characteristics data were also obtained for each subject. Daily 24-hr ambient PM10 and PM2.5 concentrations were measured at five fixed sites spaced throughout the study region. SO4 2-, which is found almost exclusively in the fine particle fraction and which does not have major indoor sources, was measured in all PM2 5 samples as an indicator of accumulation mode particu-late matter of ambient origin. |
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