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Prenatally diagnosed non-immune hydrops caused by congenital transient leukaemia |
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| Authors: | Alan E Donnenfeld MD Steven C Scott Marie Henselder-Kimmel Carlton D Dampier |
| Institution: | 1. Section of Genetics, Department of Obstetrics and Gynecology, Pennsylvania Hospital;2. Department of Obstetrics and Gynecology, West Jersey Hospital, Voorhees, NJ, U.S.A.;3. Section of Hematology—Oncology, St Christopher's Hospital for Children, Temple University School of Medicine, Philadelphia, PA |
| Abstract: | Congenital transient leukaemia (CTL) is a haematological disorder characterized by proliferation of myeloblasts within the bone marrow and peripheral blood of affected newborns. Infants with Down syndrome are most frequently affected and although the disorder can result in fetal death due to hydrops, it typically resolves spontaneously after birth. We present a case of prenatally diagnosed fetal hydrops accompanied by splenomegaly and an enlarged, echogenic liver in a fetus identified with CTL after birth. |
| Keywords: | Down syndrome congenital leukaemia splenomegaly prenatal diagnosis |