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Prenatal diagnosis of cystic fibrosis using linked DNA probes
Authors:M Schwartz  M Super  J Schmidtke  C Buys  M Farrall  D Halley  M Krawczak  J E Poncin  D Loukopoulos  M Devoto
Institution:1. Section of Clinical Genetics, Department of Pediatrics, University Hospital, Rigshospitalet, Blegdamsvej 9, DK-2100. Copenhagen 0, Denmark;2. Clinical Genetic Unit, Royal Manchester Children's Hospital, University of Manchester School of Medicine, Pendlebury, U.K.;3. Institute of Human Genetics, University of Gotlingen, Gosslerstrasse 12 d, D-3400 Göttingen, F.R.G.;4. Department of Human Genetics, Stale University of Groningen, 9713 AW Groningen, The Netherlands;5. Department of Biochemistry and Molecular Genetics, St Mary's Hospital Medical School. University of London, London, U.K.;6. Erasmus University of Rotterdam, Department of Clinical Genetics, P.O. Box 1738,3000, DR Rotterdam, The Netherlands;7. Laboratory of Clinical Chemistry, University of Liege, Sart-Tilman by Liege, Belgium;8. First Department of Internal Medicine, Laikon General Hospital, University of Athens School of Medicine, 11527 Athens, Greece;9. Genetic Molecular Laboratory, Instituto Giannina Gaslini, 16148, Geneva, Italy
Abstract:This paper presents data collected in Europe on 107 prenatal diagnoses of cystic fibrosis (CF) using linked DNA markers. To date, 38 children have been born without CF, as predicted, demonstrating the present rapid move from research to clinical genetic service.
Keywords:Cystic fibrosis  DNA markers  RFLP
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