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Reproductive behaviour and prenatal diagnosis following genetic termination of pregnancy in women of advanced maternal age |
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| Authors: | H. Brandenburg MD W. De Koning M. G. J. Jahoda Th. Stijnen M. A. J. De Ridder E. S. Sachs J. W. Wladimiroff |
| Affiliation: | 1. Departments of Obstetrics and Gynaecology Academic Hospital Rotterdam-Dijkzigt, Erasmus University, Rotterdam, The Netherlands;2. Departments of Biostatistics and Epidemiology Academic Hospital Rotterdam-Dijkzigt, Erasmus University, Rotterdam, The Netherlands;3. Departments of Clinical Genetics Academic Hospital Rotterdam-Dijkzigt, Erasmus University, Rotterdam, The Netherlands |
| Abstract: | One hundred and fifty-one women of advanced maternal age who underwent genetic termination of pregnancy (TOP) were studied for their reproductive behaviour and the type of procedure for prenatal diagnosis in a subsequent pregnancy. A total of 59 women (39 per cent) had a further pregnancy. In all continuing pregnancies prenatal diagnosis was performed, of which 75 per cent consisted of chorionic villus sampling (CVS). Reproductive behaviour following a genetic termination was negatively correlated with maternal age and parity. Both reproductive behaviour and the choice to undergo a diagnostic procedure in the next pregnancy were independent of the type of diagnostic procedure in the previous affected pregnancy. |
| Keywords: | Advanced maternal age Genetic termination Amniocentesis Chorionic villus sampling |