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Microvillar enzyme assays in amniotic fluid and fetal tissues at different stages of development |
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| Authors: | F Muller J F Oury Y Dumez J Boué A Boué |
| Institution: | 1. Institut National de la Santé et de la Recherche Médicale, Unit 73, Chǎteau de Longchamp, F-75016 Paris, France
Laboratory of Biochemistry, Hôpital Ambroise Paré, F-92104 Boulogne, France;2. Maternite Hopital Rene Dubos, F-95301 Pontoise, France;3. Clinique Universitaire Port Royal, F-75014 Paris, France;4. Institut National de la Santé et de la Recherche Médicale, Unit 73, Chǎteau de Longchamp, F-75016 Paris, France |
| Abstract: | A systematic study of microvillar enzyme activities in the amniotic fluid in correlation with their values in different fetal tissues during development has been undertaken. Microvillar enzymes appeared in the amniotic fluid at the time of disappearance of the anal membrane, 12–13 weeks, and declined from the 18th week until the 24th week. The study of fetal tissues and fluids has shown that gamma-glutamyltranspeptidase is mainly of liver origin. The significant decrease of the activities of these amniotic fluid enzymes has been the basis of prenatal diagnosis of cystic fibrosis. These assays may be useful for the diagnosis of certain digestive tract abnormalities at later stages of pregnancy. |
| Keywords: | Microvillar enzymes Amniotic fluid Fetal tissues |