Transabdominal chorionic villus sampling in the second trimester of pregnancy: Feto-maternal transfusions in relation to pregnancy outcome |
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| Authors: | F J Los MD PhD L Pijpers M G J Jahoda E S Sachs A Reuss A M Hagenaars J W Wladimiroff |
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| Institution: | 1. Department of Obstetrics and Gynaecology, Academic Hospital Rotterdam-Dijkzigt, Rotterdam, The Netherlands, Bilthoven, The Netherlands;2. Department of Clinical Genetics, Bilthoven, The Netherlands;3. Department of Clinical Chemistry, National Institute of Public Health and Environmental Protection (RIVM), Bilthoven, The Netherlands |
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| Abstract: | Volumes of feto-maternal transfusions (FMTs) in transabdominal chorionic villus sampling (TACVS) in the second trimester of pregnancy were calculated from the difference between maternal alpha-fetoprotein (AFP) concentrations before and 1 h after TACVS. In 50 pregnancies, there existed no correlation between FMT volume and the amount of villi collected or the number of TACVS attempts. The expected risk of fetal exsanguination due to very voluminous FMT could not be substantiated. In one case, immunization could have been the cause of hydrops fetalis, although only a volume of 0.15 ml could be calculated. |
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| Keywords: | Feto-maternal transfusion Transabdominal CVS Maternal serum alpha-fetoprotein |
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