| Institution: | 1. Service de Médecine et de Biologie Foetales, Institut de Puériculture de Paris, 26 Boulevard Brune, 75014 Paris, France;2. Fondation de Recherche en Hormonologie, 67–77 Boulevard Pasteur, 94260 Fresnes, France;3. Laboratoire d'Hématologie, Université de Paris-Sud, Faculté de Chatenay Malabry, 5 Rue Jean-Baptiste Clément, 92296 Chatenay Malabry, France
Service de Médecine et de Biologie Foetales, Institut de Puériculture de Paris, 26 Boulevard Brune, 75014 Paris, France |
| Abstract: | Normal levels of cancer-associated antigen (CA) 19-9, neurone-specific enolase (NSE), cancer-associated antigen (CA) 125, and mucin-like carcinoma-associated antigen (MCA) during pregnancy were determined in 87 mothers and fetuses, using a solid-phase sandwich enzyme immunoassay. CA 19-9 concentrations were higher in the fetuses, whereas the other three tumour-associated antigen levels were higher in the mothers. Only fetal NSE and MCA levels were positively correlated with those in maternal serum. Contrary to adult samples, no difference was demonstrated between male and female fetal levels of CA 125. MCA was the only maternal marker that increased significantly with gestational age between 20 and 34 weeks' pregnancy. |
