Trisomic 22 placenta in a case of severe intrauterine growth retardation |
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| Authors: | S Stioui M de Silvestris A Molinari L Stripparo L Ghisoni G Simoni |
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| Institution: | 1. Laboratorio di Citogenetica, Instituti Clinici di Perfezionamento, Milano, Italy;2. Clinica Ostetrica e Ginecologica, Università di Milano, Milano, Italy;3. Laboratorio di Citogenetica, Instituti Clinici di Perfezionamento, Milano, Italy
Clinica Ostetrica e Ginecologica, Università di Milano, Milano, Italy |
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| Abstract: | We describe a case in which a trisomic 22 placenta could be the cause of severe growth retardation in a chromosomally normal female fetus. At amniocentesis a mosaic 46,XX/ 47,XX, +22 was observed in amniotic fluid specimens sampled on two different occasions, while fetal blood from a diagnostic cordocentesis revealed a normal chromosome constitution. Postnatal studies showed the consistent presence of trisomic 22 cells in the placenta, while only normal metaphases were found in amnion, blood, and fibroblast cultures. |
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| Keywords: | Chorionic villi Trisomy 22 Chromosomal mosaicism Intrauterine growth retardation |
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