False-negative amniotic fluid acetylcholinesterase in a case of meningo-encephalocele |
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| Authors: | A Boogert J G Aarnoudse M D H W A de Bruijn A Gouw |
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| Institution: | 1. Departments of Obstetrics and Gynaecology, University Hospital Groningen, The Netherlands;2. Departments of Pathology, University Hospital Groningen, The Netherlands |
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| Abstract: | We describe a patient with a significantly elevated serum alphafetoprotein (AFP) concentration at 17 weeks of gestation, who showed only a marginally increased amniotic fluid AFP and lacked the second rapidly migrating band of acetylcholinesterase electrophoresis. Ultrasound examination revealed an encephalocele and ventriculomegaly. Autopsy showed that the encephalocele was not covered by skin. |
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| Keywords: | Amniotic fluid cholinesterase Neural tube defects |
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