Enzymatic treatment of estrogens and estrogen glucuronide |
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Authors: | Takaaki Tanak Toshiyuki Tamur Yuuichi Ishizaki Akito Kawasaki Tomokazu Kawase Masahiro Teraguchi and Masayuki Taniguchi |
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Institution: | 1. Department of Materials Science and Technology,Niigata University,Niigata 950-2181,Japan;Venture Business Laboratory,Niigata University,Niigata 950-2181,Japan 2. Department of Materials Science and Technology,Niigata University,Niigata 950-2181,Japan 3. Venture Business Laboratory,Niigata University,Niigata 950-2181,Japan 4. Department of Chemistry and Chemical Engineering,Niigata University,Niigata 950-2181,Japan |
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Abstract: | Natural and synthetic estrogens from sewage treatment systems are suspected to influence the reproductive health of the animals in the
rivers. In this article, we investigated the enzymatic treatment of three estrogens (estrone, 17 -estradiol, and 17 -ethynyletstradiol) by
a fungal laccase which oxidize phenolic compounds with dissolved oxygen. The elimination of the estrogenic activities by enzymatic
oxidation was demonstrated by medaka vitellogenin assay. In addition, we developed an enzymatic treatment system comprised of
-D-glucuronidase and the laccase for 17 -estradiol 3-( -D-glucuronide) degradation. The two enzymes eliminated 17 -estradiol 3-( -
D-glucuronide) and the intermediate, 17 -estradiol, e ciently. |
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Keywords: | enzymatic treatment laccase estrone estradiol ethynylestradiol glucuronidase glucuronide |
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