Study on increase in toxicity of Schiff bases on microorganism on chelation with metal

New heterochelates of the type M(L)(SB)(H₂O)] (where M?=?Mn(II), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II), KHL?=?potassium salt of salicylideneglycine and SB?=?thiophene- O -carboxaldeneaniline) have been synthesized. The heterochelates have been characterized on the basis of elemental analyses, electronic spectra, and magnetic measurement analyses. The structural and geometrical conformation has been discussed on the basis of IR spectral data. A thermal study of the complexes has been carried out to ascertain their thermal stability. Magnetic susceptibility measurements and electronic spectral data suggest a six-coordinated octahedral structure for these complexes. The increase in toxicity of the investigated heterochelate metal compounds was tested against three gram-negative bacteria, S. typhi, E. coli, and Serratia marcescens by the disc diffusion method. It is observed that the heterochelates show higher toxicity when compared to the Schiff bases, metal salts, and control (DMSO) due to chelation. The toxicity is also compared to the standard drug tetracycline.