Hydroxyl radical generation by redox cycling of some chemotherapeutic antibiotics |
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| Authors: | T Michalska I Kruk K Lichszteld J Kladny |
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| Institution: | 1. Institute of Physics , Technical University of Szczecin , Al. Piastów 48/49, Szczecin, 70–310, Poland;2. Clinic of General and Vascular Surgery , Pomeranian Medical Academy , Powstańców Wielkopolskich 72, Szczecin, 70–111, Poland |
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| Abstract: | The anticancer drugs: adriamycin, farmorubicin and mitomycin C greatly enhance the generation of hydroxyl radicals (HO.) from H2O2 in the presence of Co(II) ions (CoCl2) at pH 7.4 and 8, as measured by the deoxyribose assay. Catalase, hydroxyl radical scavengers (mannitol, cysteine, glutathione, thiourea, lactic dehydrogenase) inhibited the degradation of deoxyribose confirming that HO‐radicals are responsible for the degradation of the carbohydrate. |
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| Keywords: | Adriamycin farmorubicin mitomycin C hydroxyl radical cobal ions |
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