In vitro microbiological evaluation of novel 2-oxo-2H-chromene-3-carbaldehyde containing 1,3,4-thiadiazole moiety |
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| Authors: | Sevdije Govori Sabrie Spahiu Arben Haziri |
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| Institution: | 1. Department of Chemistry, Faculty of Natural Sciences, University of Pristina, Pristina, Republic of Kosovosevdije.govori@uni-pr.edu;3. Department of Chemistry, Faculty of Natural Sciences, University of Pristina, Pristina, Republic of Kosovo |
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| Abstract: | 4-(5-(Methylthio)-1,3,4-thiadiazol-2-ylamino)-2-oxo-2H-chromene-3-carbaldehyde (3) and 4-(5-(ethylthio)-1,3,4-thiadiazol-2-ylamino)-2-oxo-2H-chromene-3-carbaldehyde (4) were prepared. The structures of the newly synthesized compounds were characterized by infrared (IR), nuclear magnetic resonance (NMR) spectral data and elemental analysis. The synthesized compounds were screened in vitro for their antibacterial activities. The synthesized compounds demonstrated moderate antimicrobial activity. |
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| Keywords: | 4-chloro-2-oxo-2H-chromene-3-carbaldehyde 1 3 4- thiadiazole derivatives synthesis antimicrobial activity |
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