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Royal jelly inhibited N-acetylation and metabolism of 2-aminofluorene in human liver tumor cells (J5) |
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| Authors: | Chun S. Yu Feng T. Yeh Fu S. Yu Kwong C. Cheng |
| Affiliation: | 1. Center of General Education , China Medical University , Taichung, Taiwan, Republic of China;2. School of Dentistry , China Medical University , Taichung, Taiwan, Republic of China;3. Department of Surgery , Jen-Ai Hospital , 483, Tong-Rong Road, Tali, Taichung County 412, Taiwan, Republic of China |
| Abstract: | The present study was carried out to evaluate the question of whether or not royal jelly affects N-acetylation and metabolism of 2-aminofluorene (2-AF) in the human liver tumor cell line (J 5). N-acetylation and metabolism of 2-AF in intact J5 cells was determined by using high performance liquid chromatography for the amounts of acetylated and nonacetylated 2-AF and profile of 2-AF metabolism. The results indicated that royal jelly displayed a dose-dependent inhibition of N-acetylation of 2-AF in J5 cells. Royal jelly also decreased the profile of 2-AF metabolites in J5 cells. This report is the first demonstration which showed that royal jelly affects N-acetylation of 2-AF in human liver tumor cells (J5). |
| Keywords: | N-acetyltransferase royal jelly liver tumor cells arylamine (N-acetyl-2-aminofluorene and 2-aminofluorene) |