Protective effects of Manasamitra vatakam on aluminum-induced nephrotoxicity,oxidative stress,and histological damage |
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| Authors: | SV Thirunavukkarasu S Venkataraman S Raja L Upadhyay |
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| Institution: | 1. Department of Pharmacology , C.L. Baid Metha College of Pharmacy and Research Foundation , Thoraipakkam, Chennai-600 097, Tamil Nadu, India varasubio@rediffmail.com varasu2005@gmail.com;3. Department of Pharmacology , C.L. Baid Metha College of Pharmacy and Research Foundation , Thoraipakkam, Chennai-600 097, Tamil Nadu, India;4. Department of Pharmaceutical Chemistry , Kamalakshi Pandurangan College of Pharmacy , Tiruvannamalai, Tamilnadu, India;5. Division of Biochemistry, CARISM, SASTRA University , Thanjavur, India |
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| Abstract: | The aim of this study was to investigate the nephroprotective and antioxidant property of Manasamitra vatakam (MMV) against aluminum (Al)-induced toxicity in rats. The kidney function marker parameters such as serum urea, uric acid, and creatinine were significantly increased in Al-treated rats as compared with controls. Similarly, the antioxidant enzyme activities such as superoxide dismutase, glutathione S-transferase, Na+/K+-ATPase and Mg-ATPase, reduced glutathione were also found significantly increased in Al-treated rats. A significantly decreased level of these parameters was observed in the MMV (orally 100?mg?kg?1 body weight)-treated group along with a reduced level of malonaldehyde, molecular chaperones of an antioxidative stress protein, and mRNA expression of HSP70. The biochemical observations were also supported by histopathological observations. Thus, this study supports the nephroprotective and antioxidant activities of MMV. |
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| Keywords: | aluminum chloride Manasamitra vatakam antioxidant HSP70 kidney |
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