Antibacterial,antiviral and antioxidant activities of aerial part extracts of Peganum harmala L. grown in Tunisia |
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Authors: | H Edziri M Mastouri MA Mahjoub G Patrich M Matieu S Ammar |
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Institution: | 1. Faculté de Pharmacie, Laboratoire des Substances Biologiquement Actives et des Maladies Transmissibles , Monastir 5000, Tunisie jaziri_hayet@yahoo.fr;3. Laboratoire de Microbiologie, C H U Fattouma BOURGUIBA , Monastir 5000, Tunisie;4. Faculté des Sciences de Monastir, Laboratoire de Chimie des Substances Naturelles et de Synthèse Organique , 99/UR/12-26, Monastir 5000, Tunisie;5. Laboratoire de Microbiologie et de Virologie, H?pital Européen George Pompidou , APHP, 20 Rue Leblanc, 75905 Paris Cedex 15, France |
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Abstract: | Ethyl acetate, chloroform, butanol, and methanol extracts from the aerial part of Peganum harmala were tested for antibacterial, antioxidant, and antiviral activities. The antibacterial activity was evaluated by the determination of minimum inhibitory concentration (MIC) using the solid medium technique. Oxacillin, amoxicillin, ticarcillin, cefotaxim, and amphotericin were used as control agents. The antiviral activity was evaluated against human cytomegalovirus (HCMV) strain AD-169 (ATCC Ref. VR 538) and Coxsackie B virus type 3 (CoxB-3) using a cytopathic effect (CPE) reduction assay. The antioxidant activity was evaluated using two tests: 1,1-diphenyl-2-picrylhydrazyl (DPPH) free-radical scavenging and ammonium thiocyanate methods. Among tested extracts; the chloroform extract displayed a higher antibacterial activity against Gram-positive than Gram-negative bacteria. The butanol extract demonstrated the highest antioxidant activity. The methanol extract showed significant antiviral activity against CoxB-3 virus. The chloroform extract may be an important source of bactericidal compounds against Gram-positive bacteria. |
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Keywords: | Peganum harmala antimicrobial antiviral antioxidant activities aerial part |
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