Effects of nanopesticide chlorfenapyr on mice |
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Authors: | Shi Wan-Jun Shi Wei-Wei Gao Sai-Yan Lu Yi-Tong Cao Yong-Song |
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Institution: | Key Laboratory of Urban Agriculture (South) of Ministry of Agriculture, Shanghai Jiaotong University , No. 800 Dongchuan Road, Shanghai 200240, P.R. China |
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Abstract: | The effects of chlorfenapyr nano preparation on mice were examined. The animals were administered with different doses of 4.84, 9.68, or 19.36?mg?kg?1 of chlorfenapyr common preparation or nano preparation intraperitoneally (IP). Micronucleus (MN) test and comet assay (CA) experiments revealed that at the same dose, similar DNA damage in the peripheral blood lymphocytes of the mouse and chromosome damage in bone marrow cells of the mouse occurred with chlorfenapyr nano preparation; however, the severity of these effects was less than that found in common preparation. It is noteworthy that there were no differences in apoptotic ratio and live cell percentage in the liver cells of the mouse between these two pesticide formulations using flow cytometry. Data indicate that chlorfenapyr nanoformulation is less toxic to mouse cells than the common formulation. |
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Keywords: | nanopesticide chlorfenapyr toxicity analysis mice |
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