Synthesis and in vitro biological evaluation of 3, 4-annelated coumarin-pyrimido-pyrimidine systems |
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| Authors: | Sevdije Govori Vuksan Kalaj Osman Leci |
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| Institution: | 1. Faculty of Natural Sciences, Department of Chemistry, University of Pristina, Pristina, Republic of Kosovosevdije.govori@uni-pr.edu;3. Faculty of Natural Sciences, Department of Chemistry, University of Pristina, Pristina, Republic of Kosovo |
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| Abstract: | 3,4-Annelated coumarin-pyrimido-pyrimidine systems (7-imino-8-mercapto-7H-5-oxa-7a,9,12-triaza-benzoa]anthracen-6-one 2 and 8-hydroxy-7-imino-10-methyl-7H-5-oxa-7a,9,12-triaza-benzoa]anthracen-6-one 3) were synthesized by the action of 4-amino-2-mercapto-pyrimidine, 2-amino-4-hydroxy-6-methylpyrimidine, respectively, on 4-chlorocoumarin-3-carbonitrile 1. The synthesized compounds were examined for in vitro antibacterial activity against 4 bacterial cultures: Staphylococcus aureus, Streptococcus pneumonia, Escherichia coli, and Aeromonas Salmonicida. The antibacterial activity of synthesized compounds 2 and 3 was compared to antibacterial activity of novobiocin as a standard drug. |
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| Keywords: | 4-chlorocoumarin-3-carbonitrile pyrimidine synthesis antibacterial activity Staphylococcus aureus Streptococcus pneumoni Escherichia coli Aeromonas Salmonicida novobiocin |
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