A study of biochemical parameters among individuals residing in a fluoride endemic area in India |
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| Authors: | Dr B Ravichandran A Roychowdhury S Chattopadhyay P K Gangopadhyay H N Saiyed |
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| Institution: | 1. Regional Occupational Health Centre (S) , Bangalore Medical College campus , Bangalore – 560 002, India ravichandran65@yahoo.com;3. Regional Occupational Health Centre (E) , Kolkata;4. Department of Life Sciences and Biotechnology , Jadavpur University , Kolkata;5. National Institute of Occupational Health , Ahmedabad |
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| Abstract: | Fluoride (Fl) exerts an inhibitory effect on many metabolic enzymes of various tissues. A study was carried out among individuals residing in a Fl-affected area in India. The biochemical parameters including serum enzyme activities of alkaline phosphatase (ALKP), glutamic pyruvic transaminase (SGPT), lactate dehydrogenase (LDH), and serum creatinine (CRTN) were estimated in 259 subjects compared to 233 controls. The results showed that among the Fl-exposed population, ALKP and SGPT were significantly increased compared to control. The CRTN levels were also significantly increased compared to the control subjects. LDH levels were not markedly altered. Data suggest that Fl exposure affects renal and hepatic functions in endemic areas of India. |
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| Keywords: | Fluoride SGPT ALKP LDH creatinine |
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