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Assessment of the neurotoxicity of intramuscular artemether in mice |
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| Authors: | AS Adekunle EO Agbedana AO Oyewopo |
| Institution: | 1. Department of Biochemistry , Ladoke Akintola University of Technology , Box 14066, U.I. Ibadan, Ogbomoso, Oyo, Nigeria kunleniran@yahoo.com;3. Department of Chemical Pathology , University of Ibadan , Ibadan, Nigeria;4. Department of Anatomy , University of Ilorin , Ilorin, Nigeria |
| Abstract: | Artemether has been shown to be a very reliable antimalarial drug particularly because of its potency against multidrug resistant strain of malaria parasite; however, there is concern about its potential toxic effects. This study was designed to evaluate the neurotoxic effect of artemether using a mouse model. The photomicrographs of brains of the mice in the different artemether treated groups showed neurodegeneration. This observation is an indication that artemether may be neurotoxic in mice. |
| Keywords: | artemether neurotoxic antimalaria multidrug resistant brain neurodegeneration |