Changes in cardiac rhythm and calcium levels in guinea pigs treated chronically with fenitrothion |
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| Authors: | M Anand A Gulati K Gopal R N Khanna P K Ray O N Tripathi |
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| Institution: | 1. Industrial Toxicology Research Centre , Post Box No. 80, Mahatma Gandhi Marg, Lucknow, 226001, India;2. Central Drug Research Institute , Post Box No. 173, Chattar Manzil Palace, Lucknow, 226001, India |
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| Abstract: | Fenitrothion, an acetylcholinesterase inhibitor, causes bradycardia following long‐term exposure. To analyse the mechanism underlying these cardiac changes, ginea pigs were exposed to fenitrothion 5 and 10 mg/kg for 30 consecutive days. Electrocardiogram (ECG) showed increase in PR and RR intervals. These changes were more prominent in the animals receiving 10 mg/kg fenitrothion which occasionally showed extrasystoles. In isolated atria preparation heart rate was decreased at higher dose. Amplitude of cardiac rhythm decreased with respect to increased ACh concentration. Hypocalcemia was recorded in fenitrothion‐treated animals. The residual content of fenitrothion was increased in both groups of animals following a pattern: brain> spleen> heart> liver> kidney. |
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| Keywords: | Fenitrothion electrocardiogram acetylcholine hypocalcemia bradycardia |
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