Antidiabetic effects of Trigonella foenum-graecum seed powder in a rat model |
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| Authors: | Pardeep Kumar RK Kale Somnath Mukherjee Krishna Prakash P McLean |
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| Institution: | 1. School of Life Sciences , Jawaharlal Nehru University , New Delhi, 110067 India;2. Division of Biosciences, Faculty of Life Sciences , University College London Medical School , London W1T 4JF, UK |
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| Abstract: | Free radical production and oxidative stress are known to increase in liver during diabetes and may contribute to oxidative damage. In this study, the effect of oral feeding of Trigonella foenum-graecum seed powder (TSP) has been studied on blood glucose, membrane-linked ATPases, antioxidant enzymes, lipid peroxidation, lipofuscin content and membrane fluidity in livers of a diabetic rat. Diabetes was induced by administration of alloxan monohydrate. Hyperglycemia during diabetes has been shown to entail free radical generation, with a concomitant increase in lipid peroxidation and lipofuscin content, inhibition of membrane-linked ATPases, increased antioxidant enzyme activities and decreased membrane fluidity. TSP treatment reverses the changes to near normal levels thereby ameliorating the management of diabetic complications. |
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| Keywords: | diabetes antioxidant status Trigonella foenum-graecum seed powder (TSP) liver membrane linked ATPases oxidative stress |
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