Oleuropein alleviates malathion-induced oxidative stress and DNA damage in rats |
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| Authors: | Funda Karabag-Coban Ibrahim Bulduk Recep Liman Ibrahim Cigerci Omer Hazman |
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| Institution: | 1. Department of Molecular Biology and Genetic, Faculty of Arts and Science, Usak University, Usak, Turkey;2. Usak Health Training School, Usak University, Usak, Turkey;3. Department of Molecular Biology and Genetic, Faculty of Science and Arts, Afyon Kocatepe University, Afyonkarahisar, Turkey;4. Department of Chemistry, Faculty of Science and Arts, Afyon Kocatepe University, Afyonkarahisar, Turkey |
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| Abstract: | The effects of acute exposure to 250 mg/kg malathion and the protective effects of 20 mg/kg oleuropein, both administered intraperitoneally, were evaluated in Wistar male rats. Malathion administration increased malondialdehyde, nitric oxide, 8-hydroxy-2′-deoxyguanosine, total oxidant status, and DNA damage, yet decreased total antioxidant activity, superoxide dismutase, and catalase activities in blood, liver, and kidney. Administration of oleuropein reversed malathion-induced oxidative stress, lipid peroxidation, DNA damage, and antioxidant enzyme activity. |
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| Keywords: | malathion oleuropein oxidative stress DNA damage rat |
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