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SAFE—The Special Non-invasive Advances in Fetal and Neonatal Evaluation Network: aims and achievements
Authors:Lyn S Chitty  C Ellen van der Schoot  Sinuhe Hahn  Neil D Avent
Institution:1. Clinical and Molecular Genetics Unit, Institute of Child Health and Fetal Medicine Unit, University College London NHS Foundation Trust, London, UK;2. Department of Experimental Immunohematology, Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands;3. University Women's Hospital/Department of Research, University Hospital Basel, Switzerland;4. Centre for Research in Biomedicine, Faculty of Health and Life Sciences, University of the West of England, Bristol
Abstract:In this short review, the objectives and work of SAFE—the Special Non-invasive Advances in Fetal and Neonatal Evaluation Network, a European Union Framework VI network of excellence is described. We demonstrate how this network facilitates the implementation of non-invasive prenatal diagnosis (NIPD) for single gene disorders, fetal rhesus typing, aneuploidy and pregnancy complications. Copyright © 2008 John Wiley & Sons, Ltd.
Keywords:non-invasive prenatal diagnosis  free-fetal DNA  proteomics  fetal sex determination  prenatal diagnosis of aneuploidy  fetal rhesus status
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