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Prospective experience with integrated prenatal screening and first trimester combined screening for trisomy 21 in a large Canadian urban center
Authors:Nanette Okun  Anne M Summers  Barry Hoffman  Tianhua Huang  Elizabeth Winsor  David Chitayat  A Staines  Jo-Ann Johnson
Institution:1. Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada;2. Genetics Program, North York General Hospital, Toronto, Ontario, Canada

Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada;3. Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada;4. Genetics Program, North York General Hospital, Toronto, Ontario, Canada;5. Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada;6. Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada

Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada;7. Department of Obstetrics and Gynecology, University of Calgary, Calgary, Alberta, Canada

Abstract:
Keywords:first trimester combined screening  integrated prenatal screening  detection rate  false positive rate  trisomy 21
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