Environmental ozone exposure and oxidative DNA damage in adult residents of Florence, Italy |
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Authors: | Palli Domenico Sera Francesco Giovannelli Lisa Masala Giovanna Grechi Daniele Bendinelli Benedetta Caini Saverio Dolara Piero Saieva Calogero |
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Institution: | a Molecular and Nutritional Epidemiology Unit, Cancer Prevention and Research Institute (ISPO), Via Cosimo il Vecchio 2, 50139 Florence, Italy b Department of Pharmacology, University of Florence, Viale G.Pieraccini 6, 50139 Florence, Italy c Regional Environmental Protection Agency of Tuscany (ARPAT), Via Porpora 22, 50144 Florence, Italy |
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Abstract: | In 71 adults residing in Florence, Italy, enrolled in a prospective study, we investigated the correlation between individual levels of oxidative DNA damage detected by the Comet assay in circulating lymphocytes, and a specific ozone exposure score calculated in 10 different time-windows (0-5 to 0-90 days) before blood drawing, based on daily measurements provided by the local environmental monitoring system.Overall, statistically significant positive correlations between average ozone concentrations and DNA damage emerged in almost all time-windows considered; correlations were more evident among males, non-smokers, and traffic-exposed workers. Multivariate regression analyses taking into account selected individual characteristics, showed an independent effect on DNA damage of average ozone concentrations in the last 60-90 days before blood drawing. Local residents showed a divergent pattern with correlations restricted to shorter time-windows.Our results suggest that ozone concentrations at ground levels modulate oxidative DNA damage in circulating lymphocytes of residents of polluted areas. |
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Keywords: | Environmental pollution Ozone DNA oxidative damage Smoking Occupational exposure |
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