Effect of illumination regime on life span in <Emphasis Type="Italic">Drosophila melanogaster</Emphasis>

Accelerated aging of Drosophila strains with impaired detoxification of free radicals (Sod) and DNA repair (mus-210) under illumination as compared to the wild type has been demonstrated. In contrast, in a strain carrying a defective homolog of mammalian gene PCNA, the life span increases under conditions of round-the-clock illumination compared to constant darkness. The first review of the possible mechanisms underlying the effect of the illumination regime on the life span is presented, with special emphasis on the roles of the disturbance of normal circadian rhythms, increase in fecundity and physical activity (metabolic rate), and the neuroendocrine control of the insulin/IGF-1 pathway.