含铅,无铅汽油车尾气排出物遗传毒性比较

利用台架试验模拟汽车行驶工况，收集了发动机使用无铅汽油，含铅汽油燃烧后的尾气颗粒物，对其中吸附的有机物进行了提取，并以Ａｍｅｓ试验，中国仓鼠肺细胞体外微核实验等方法，从基因，染色体水平检测了两种颗粒提取的遗传毒性。

Comparison on Genotoxiocity of Two Vehicle Exhausts Using Leaded and Unleaded Gasoline

Two kinds of gasoline (leaded and unleaded) have been tested on Engine Dynamometer, the total paniculate matter of exhausts were collected, and from which the organic substances were extracted. By using Ames test and micronucleus assay in CHL cells, genotoxicity of two kinds of extracted organic substances were determined from the end points of gene and chromosome, the results showed that unleaded gasoline has the potential of reducing emission of particles, but both kinds of extract could increase the number of histidine-independent colonies in salmonells/ microsomal test and induce micronuclei in CHL cells, and also dose-response relationship were found. As the same particles were being tested, there were no significant differences in genotoxicity between two kinds of extracts.