Exposure to fine particle matter,nitrogen dioxide and benzene during pregnancy and cognitive and psychomotor developments in children at 15 months of age |
| |
| Institution: | 1. Faculty of Medicine, University of the Basque Country (UPV/EHU), Leioa, Basque Country, Spain;2. BIODONOSTIA Health Research Institute, San Sebastian, Basque Country, Spain;3. Department of Statistics, Informatics and Applications “G. Parenti”, University of Florence, Italy;4. Biostatistics Unit, Cancer Prevention and Research Institute (ISPO), Florence, Italy;5. Faculty of Psychology, University of the Basque Country UPV/EHU, San Sebastian, Basque Country, Spain;6. Department of the Environment and Regional Planning, Government of the Basque Country, Vitoria, Spain;7. Public Health Laboratory, Department of Health, Government of the Basque Country, Bilbao, Spain;8. Sub-Directorate for Public Health of Guipúzcoa, Department of Health, Government of the Basque Country, San Sebastian, Spain;9. Biomedical Research Centre Network for Epidemiology and Public Health (CIBERESP), Spain;1. MRI Research Unit, Hospital del Mar, Barcelona, Spain;2. Centro Investigación Biomédica en Red de Salud Mental, CIBERSAM G21, Barcelona, Spain;3. Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, Spain;4. Pompeu Fabra University, Barcelona, Catalonia, Spain;5. Ciber on Epidemiology and Public Health (CIBERESP), Spain;6. Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Barcelona, Catalonia, Spain;7. Radiology Department, Hospital del Mar, Barcelona, Spain;8. Department of Clinical and Health Psychology, Autonomous University of Barcelona, Spain;9. Instituto Universitario de Neurorrehabilitación Guttmann, Badalona, Spain;10. IMIM (Hospital del Mar Medical Research Institute), Barcelona, Catalonia, Spain;1. Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium;2. Integrated Psychiatric Centre OPZ, Geel, Belgium;3. Department of Analytical and Environmental Chemistry, Vrije Universiteit Brussel (VUB), Brussels, Belgium;4. Department of Radiotherapy and Nuclear Medicine, Ghent University, Ghent, Belgium;5. Flemish Institute for Technological Research, Environmental Risk and Health, Mol, Belgium;6. Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium;7. Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Diepenbeek, Belgium;8. Department of Public Health, Ghent University, Ghent, Belgium;9. Louvain Centre for Toxicology and Applied Pharmacology (LTAP), Université Catholique de Louvain, Brussels, Belgium;10. Department of Neurology, Sint Dimphna Hospital, Geel, Belgium;11. School of Public Health, Occupational and Environmental Medicine, KU Leuven, Leuven, Belgium;1. Department of Preventive Medicine, Ewha Medical Research Center, Ewha Womans University, Seoul, South Korea;2. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea;3. Department of Preventive Medicine, College of Medicine, Dankook University, Cheonan, South Korea;4. Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea;5. Division of Child & Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea;6. Department of Adolescent Psychiatry, National Center for Child and Adolescent Psychiatry, Seoul National Hospital, Seoul, South Korea;7. Institute for Environmental Research, Yonsei University, Seoul, South Korea;8. Environmental Health Research Division, National Institute of Environmental Research, Incheon, South Korea |
| |
| Abstract: | BackgroundPrenatal exposure to air pollutants has recently been identified as a potential risk factor for neuropsychological impairment.ObjectivesTo assess whether prenatal exposure to fine particulate matter (PM2.5), nitrogen dioxide (NO2) and benzene were associated with impaired development in infants during their second year of life.MethodsRegression analyses, based on 438 mother–child pairs, were performed to estimate the association between mother exposure to air pollutants during pregnancy and neurodevelopment of the child. The average exposure to PM2.5, NO2 and benzene over the whole pregnancy was calculated for each woman. During the second year of life, infant neuropsychological development was assessed using the Bayley Scales of Infant Development. Regression analyses were performed to estimate the association between exposure and outcomes, accounting for potential confounders.ResultsWe estimated that a 1 μg/m3 increase during pregnancy in the average levels of PM2.5 was associated with a ? 1.14 point decrease in motor score (90% CI: ? 1.75; ? 0.53) and that a 1 μg/m3 increase of NO2 exposure was associated with a ? 0.29 point decrease in mental score (90% CI: ? 0.47; ? 0.11). Benzene did not show any significant association with development. Considering women living closer (≤ 100 m) to metal processing activities, we found that motor scores decreased by ? 3.20 (90% CI: ? 5.18; ? 1.21) for PM2.5 and ? 0.51 (? 0.89; ? 0.13) for NO2, while mental score decreased by ? 2.71 (90% CI: ? 4.69; ? 0.74) for PM2.5, and ? 0.41 (9% CI: ? 0.76; ? 0.06) for NO2.ConclusionsOur findings suggest that prenatal residential exposure to PM2.5 and NO2 adversely affects infant motor and cognitive developments. This negative effect could be higher in the proximity of metal processing plants. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
