| 环境暴露致秀丽线虫衰老毒性及相关作用机制研究进展 |
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| 引用本文： | 武秋立,王大勇.环境暴露致秀丽线虫衰老毒性及相关作用机制研究进展[J].环境污染与防治,2011,33(10):73-78. |
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| 作者姓名： | 武秋立 王大勇 |
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| 作者单位： | 东南大学医学院,江苏 南京,210009 |
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| 基金项目： | 国家重点基础研究发展计划资助项目(No.2011CB933404) |
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| 摘 要： | 衰老作为一个重要的评价终点,目前已经广泛应用于秀丽线虫环境暴露评价以及相关毒理学研究.系统总结了各种金属以及有机污染物暴露所致秀丽线虫衰老毒性;分析了胰岛素信号、应激反应与氧化应激、线粒体呼吸链、金属硫蛋白、金属诱导胁迫响应蛋白NUMR-1和NUMR-2等在环境暴露致秀丽线虫衰老毒性形成中的重要调控功能;指出了代谢变化...
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| 关 键 词： | 衰老 环境暴露 毒性评价 毒害机制 秀丽线虫 |
Progresses on induction of toxicity on longevity by environmental exposure and the related toxicology in nematode Caenorhabditis elegans |
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| WU Qiuli,WANG Dayong.Progresses on induction of toxicity on longevity by environmental exposure and the related toxicology in nematode Caenorhabditis elegans[J].Environmental Pollution & Control,2011,33(10):73-78. |
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| Authors: | WU Qiuli WANG Dayong |
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| Institution: | WU Qiuli,WANG Dayong.(School of Medical,Southeast University,Nanjing Jiangsu 210009) |
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| Abstract: | In model animal of Caenorhabditis elegans,aging has gradually become a widely used endpoint for evaluation of environmental safety and toxicology.In this review,the induction of toxicity on longevity by different metals and organic pollutants in Caenorhabditis elegans was first summarized;Moreover,we discussed the important roles of insulin signals,stress response and oxidative stress,mitochondria respiratory chain,metallothioneins and metal responsive protein(NUMR-1,NUMR-2) in regulating the formation of t... |
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| Keywords: | aging environmental exposure toxicity evaluation toxicology Caenorhabditis elegans |
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