某污水灌区居民胃癌高发的病因研究

某污水灌区居民恶性肿瘤死亡回顾调查发现,胃癌标化死亡率重污染地区明显高于一般污染区及对照区,是全国农村胃癌标化死亡率的3倍.通过污灌区居民临床体检和肠型胃癌的肠上皮抗原——α_2GP 对血清免疫学检测,发现胃癌高发与本地人群慢性萎缩性胃炎的粘膜肠上皮化生有密切联系,环境卫生与环境流行病学调查进一步证明污灌地区居民的胃粘膜肠上皮化生又和灌区污染的井水及稻米中某些矿物油、苯并(a)芘等污染物长期刺激有关,经试验均具有效突变活性.据此,作者初步提示了某污灌区居民胃癌的发生模型.

ETIOLOGICAL STUDY OF INCREASED STOMACH CANCER IN A WASTEWATER IRRIGATED AREA

The retrospective investigation study on a Wastewter irrigated area shows that the standardization mortality of stomach cancer in the heavily polluted area is significantly higher than that of the slightly polluted and control area,which is 3 times that of the general level of the countryside.Clinical examination and serum immunity test of α_2IGP(intestines cell antigen of stomach cancer)found a close relationship between stomach cancer and chronic atrophic gastritis. Further environmental investigation demonstrated that the intestine epithelium metaplasia of gastric mucous membrane was related to the chronic stimuation of some mineral oils and B(a)P in the well water and rice of the irrigated area,which have been confirmed to have matagnic activity. Based on all these facts a simulator of stomach cancer in the irrigated area was suggested.