Division of Genetics, Department of Pediatrics, Floating Hospital for Children at Tufts Medical Center, Boston, MA, USA;2. Division of Genetics, Department of Pediatrics, Floating Hospital for Children at Tufts Medical Center, Boston, MA, USA;3. Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA;4. Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA;5. Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Tufts Medical Center, Boston, MA, USA